Endocrine Abstracts

In order to compare effects of treatment in hyperthyroid patients treated with thyrostatic drug alone and those treated with thyrostatic plus levothyroxine we reviewed data from 60 consecutive patients attending our outpatient clinic. 27 patients, 25 ♀ and 2 ♂, aged 27–68 years were treated with thyrostatic drug alone, while 33 patients, 31 ♀ and 2 ♂, aged 19–88 years received thyrostatic plus levothyroxine. Number of remissions was greate...

We retrospectively collected data from 62 pregnant females who were followed for hyperthyroidism (n=17), hypothyroidism (n=21), euthyroid Hashimoto’s thyroiditis (n=9), and simple goitre and other non-autoimmune thyroid diseases (n=15).Among them 33 showed at least once during pregnancy low FT4, or low FT3 and FT4 in total on 74 occasions. Low FT4 was found on 15, low FT3 on 15 and low FT<s...

Last 10 years, we are living in iodine sufficient environment. To clarify natural course of thyroid autonomy in this conditions, we investigated 100 consecutive patients in last three months – 93 female and 7 male aged 19–86 years. Included were patients with scans showing thyroid autonomy, and patients with nodular or diffuse goiter with low or suppressed TSH. We followed them from their first visit. Thirty patients were hyperthyroid – one spontaneously cured, ...

Background: Hyperthyroidism is associated with an increased risk of atherothrombosis and venous thrombotic events by mechanisms that are not fully understood. Previous work has shown that blood clot structure determines the susceptibility to thrombosis and therefore the aim of this study was to investigate the effects of hyperthyroidism on clot structure and fibrinolysis.Methods: Six patients with hyperthyroidism were included in a pilot longitudinal stu...

Background: Currently, the European Society of Endocrinology guidelines asserted against additional imaging during follow-up (FUP) in patients with non-functioning adrenal masses <4 cm in size with clear benign features on imaging studies. Our analysed literature data suggests that an increase (minimum 1 cm) in an initially benign adrenal mass during follow-up occurs in 3.5–20% of patients with adrenal incidentalomas.Aim: To analyse the change i...

Chronic hypoparathyroidism (HypoPT) is a rare disease associated with a variety of symptoms and diminished health-related quality of life (HRQoL). This study aimed to characterise and quantify the symptom burden, HRQoL, and overall disease impact in patients receiving recombinant human parathyroid hormone (rhPTH1-84, Natpar®) for inadequately controlled HypoPT and in symptomatic patients receiving standard therapy (ST; calcium and/or vitamin D supplements). A w...

Introduction Retrospective analyses suggest that patients with adrenal insufficiency (AI) have an increased risk for cardiovascular diseases which was mainly attributed to non-physiological cortisol profiles and/or supraphysiological replacement doses.Material and methodsWe analyzed the 24-hour blood pressure (BP) profiles in patients with primary (PAI) and secondary (SAI) AI. BP threshold criteria for hypert...

Introduction: Retrospective analyses suggest an increased risk for cardiovascular diseases in patients with adrenal insufficiency (AI), mainly due to supraphysiological replacement doses.Objective: To evaluate the 24-hour blood pressure (BP) profile in patients with primary (PAI) and secondary (SAI) AI.Material and methods: BP threshold criteria for hypertension and dipping status of the 2018 ESC/ESH guidelines were used (24-h: &#8...

Background: Ischemic heart disease (IHD) is one of the leading causes of death worldwide. Thus, there is the necessity to find new therapeutic approaches. Thyroid hormones (TH) have a major impact on cardiac function and even appear to improve the outcome after acute ischemia/reperfusion and in chronic heart failure. Still, TH signaling within the heart is not yet completely understood.Aim: This project aims to investigate the influence of TH receptor al...

Ischemic heart disease (IHD) is one of the leading causes of death worldwide. TH have impact on cardiac function and even appear to improve outcome after acute ischemia/reperfusion and in chronic heart failure. This project aims to investigate the influence of TH receptor alpha (TRα) on IHD using specific mouse models to assess the contribution of canonical vs. non-canonical TH signaling. Mice underwent permanent ligation of the left descending coronary artery and were tr...